Revue du rôle possible de la vitamine D dans le traitement de la COVID-19 et recommandations pratiques

Poulin, David

doi:https://doi.org/10.7202/1084270ar

1. Chen P-L, Lee N-Y, Cia C-T, Ko W-C, Hsueh P-R. A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs. Front Pharmacol. 2020 ;11:584956.

Google Scholar 10.3389/fphar.2020.584956

2. World Health Organization. Therapeutics and COVID-19: living guideline [En ligne]. 2021 [cité le 9 avril 2021 ]. Disponible : https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2021.1.

Google Scholar

3. Martineau AR, Forouhi NG. Vitamin D for COVID-19: a case to answer ? The Lancet Diabetes & Endocrinology. 2020 ;8(9):735-6.

Google Scholar 10.1016/S2213-8587(20)30268-0

4. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 ;21(3):319-29.

Google Scholar 10.1016/j.chembiol.2013.12.016

5. Marino R, Misra M. Extra-Skeletal Effects of Vitamin D. Nutrients. 2019 ;11(7):1460.

Google Scholar 10.3390/nu11071460

6. Wacker M, Holick MF. Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013 ;5(1):111-48.

Google Scholar 10.3390/nu5010111

7. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Reviews in Endocrine and Metabolic Disorders. 2017 ;18(2):153-65.

Google Scholar 10.1007/s11154-017-9424-1

8. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et coll. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of clinical endocrinology and metabolism. 2011 ;96(1):53-8.

Google Scholar 10.1016/j.jada.2011.01.004

9. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism. 2011 ;96(7):1911-30.

Google Scholar 10.1210/jc.2011-0385

10. Gilbert CR, Arum SM, Smith CM. Vitamin D deficiency and chronic lung disease. Can Respir J. 2009 ;16(3):75-80.

Google Scholar 10.1155/2009/829130

11. Dancer RC, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax. 2015 ;70(7):617-24.

Google Scholar 10.1136/thoraxjnl-2014-206680

12. Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Kerley CP, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med. 2017 ;5(11):881-90.

Google Scholar 10.1016/S2213-2600(17)30306-5

13. Zhu M, Wang T, Wang C, Ji Y. The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis. International journal of chronic obstructive pulmonary disease. 2016 ;11:2597-607.

Google Scholar 10.2147/COPD.S101382

14. Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ (Clinical research ed). 2017 ;356:i6583.

Google Scholar 10.1136/bmj.i6583

15. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 ;324(8):782-93.

Google Scholar 10.1001/jama.2020.12839

16. Zambrano LD, Ellington S, Strid P, Galang RR, Oduyebo T, Tong VT, et coll. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020 ;69(44):1641-7.

Google Scholar 10.15585/mmwr.mm6925a1

17. Malek Mahdavi A. A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Reviews in medical virology. 2020 ;30(5):e2119.

Google Scholar 10.1002/rmv.2119

18. Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015 ;7(6):4240-70.

Google Scholar 10.3390/nu7064240

19. Hansdottir S, Monick MM. Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm. 2011 ;86:217-37.

Google Scholar 10.1016/B978-0-12-386960-9.00009-5

20. Bleizgys A. Vitamin D and COVID-19: It is time to act. International Journal of Clinical Practice. 2020 ;75:e13748.

Google Scholar 10.1111/ijcp.13748

21. Chen H, Lu R, Zhang Y-G, Sun J. Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs. Tissue Barriers. 2018 ;6(4):1-13.

Google Scholar 10.1080/21688370.2018.1540904

22. Rehan VK, Torday JS, Peleg S, Gennaro L, Vouros P, Padbury J, et al. 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells. Molecular genetics and metabolism. 2002 ;76(1):46-56.

Google Scholar 10.1016/S1096-7192(02)00022-7

23. Merzon E, Tworowski D, Gorohovski A, Vinker S, Golan Cohen A, Green I, et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. FEBS J. 2020 ;287(17):3693-702.

Google Scholar 10.1111/febs.15495

24. Mardani R, Alamdary A, Mousavi Nasab SD, Gholami R, Ahmadi N, Gholami A. Association of vitamin D with the modulation of the disease severity in COVID-19. Virus Research. 2020 ;289:198148.

Google Scholar 10.1016/j.virusres.2020.198148

25. Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Van den Abbeele K, et al. Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgraduate medical journal. 2020 ;138712.

Google Scholar 10.1136/postgradmedj-2020-138712

26. Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. International Journal of Infectious Diseases. 2021 ;104:58-64.

Google Scholar 10.1016/j.ijid.2020.12.077

27. Hernández JL, Nan D, Fernandez-Ayala M, García-Unzueta M, Hernández-Hernández MA, López-Hoyos M, et al. Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection. The Journal of clinical endocrinology and metabolism. 2021 ;106(3):e1343-e53.

Google Scholar 10.1210/clinem/dgaa733

28. Im JH, Je YS, Baek J, Chung M-H, Kwon HY, Lee J-S. Nutritional status of patients with COVID-19. Int J Infect Dis. 2020 ;100:390-3.

Google Scholar 10.1016/j.ijid.2020.08.018

29. Ye K, Tang F, Liao X, Shaw BA, Deng M, Huang G, et al. Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity ?-A Case-Control Study. Journal of the American College of Nutrition [En ligne]. 13 oct 2020 [cité le 20 mars 2021]:[environ 8 p.] Disponible : https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1826005

Google Scholar 10.1080/07315724.2020.1826005

30. Abdollahi A, Kamali Sarvestani H, Rafat Z, Ghaderkhani S, Mahmoudi-Aliabadi M, Jafarzadeh B, et al. The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID-19 infection: A case–control study of hospitalized patients in Tehran, Iran. Journal of medical virology. 2021 ;93(4):2359-64.

Google Scholar 10.1002/jmv.26726

31. Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, et al. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 ;13(3):717.

Google Scholar 10.3390/nu13030717

32. Luo X, Liao Q, Shen Y, Li H, Cheng L. Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People. The Journal of nutrition. 2021 ;151(1):98-103.

Google Scholar 10.1093/jn/nxaa332

33. Pereira M, Dantas Damascena A, Galvão Azevedo LM, de Almeida Oliveira T, da Mota Santana J. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Critical reviews in food science and nutrition [En ligne]. 4 nov 2020 [cité le 20 mars 2021]:[environ 9 p.] Disponible : https://www.tandfonline.com/doi/full/10.1080/10408398.2020.1841090.

Google Scholar 10.1080/10408398.2020.1841090

34. D’Avolio A, Avataneo V, Manca A, Cusato J, De Nicolò A, Lucchini R, et coll. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients. 2020 ;12(5):1359.

Google Scholar 10.3390/nu12051359

35. Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz CL, et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr. 2020 ;14(4):561-5.

Google Scholar 10.1016/j.dsx.2020.04.050

36. Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PloS one. 2020 ;15(9):e0239252.

Google Scholar 10.1371/journal.pone.0239252

37. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. JAMA Network Open. 2020 ;3(9):e2019722.

Google Scholar 10.1001/jamanetworkopen.2020.19722

38. Katz J, Yue S, Xue W. Increased risk for COVID-19 in patients with vitamin D deficiency. Nutrition. 2020 ;84:111106.

Google Scholar 10.1016/j.nut.2020.111106

39. Amin HA, Drenos F. No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data. BMJ Nutr Prev Health. 2021:bmjnph-2020-000151.

Google Scholar 10.1136/bmjnph-2020-000151

40. Orchard L, Baldry M, Nasim-Mohi M, Monck C, Saeed K, Grocott MPW, Ahilanandan D. Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients. Clin Chem Lab Med. 2021 Jan 19 ;59(6):1155-1163.

Google Scholar 10.1515/cclm-2020-1567

41. Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U. Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients. 2020 ;12(9).

Google Scholar 10.3390/nu12092757

42. Gavioli EM, Miyashita H, Hassaneen O, Siau E. An Evaluation of Serum 25-Hydroxy Vitamin D Levels in Patients with COVID-19 in New York City. Journal of the American College of Nutrition [En ligne]. 19 fév 2021[cité le 20 mars 2021]:[environ 6 p.]. Disponible : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898298/

Google Scholar 10.1080/07315724.2020.1869626

43. Angelidi AM, Belanger MJ, Lorinsky MK, Karamanis D, Chamorro-Pareja N, Ognibene J, et al. Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients. Mayo Clinic Proceedings. 2021 ;96(4):875-86.

Google Scholar 10.1016/j.mayocp.2021.01.001

44. Jain A, Chaurasia R, Sengar NS, Singh M, Mahor S, Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Scientific Reports. 2020 ;10(1):20191.

Google Scholar 10.1038/s41598-020-77093-z

45. Abrishami A, Dalili N, Mohammadi Torbati P, Asgari R, Arab-Ahmadi M, Behnam B, Sanei-Taheri M. Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study. Eur J Nutr. 2021 Jun ;60(4):2249-2257.

Google Scholar 10.1007/s00394-020-02411-0

46. Ricci A, Pagliuca A, D’Ascanio M, Innammorato M, De Vitis C, Mancini R, et al. Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients. Respiratory research. 2021 ;22(1):76.

Google Scholar 10.1186/s12931-021-01666-3

47. Demir M, Demir F, Aygun H. Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease. Journal of medical virology. 2021 ;93(5):2992-9.

Google Scholar 10.1002/jmv.26832

48. Basaran N, Adas M, Gokden Y, Turgut N, Yildirmak T, Guntas G. The relationship between vitamin D and the severity of COVID-19. Bratislavske lekarske listy. 2021 ;122(3):200-5.

Google Scholar 10.4149/BLL_2021_034

49. Munshi R, Hussein MH, Toraih EA, Elshazli RM, Jardak C, Sultana N, et al. Vitamin D insufficiency as a potential culprit in critical COVID-19 patients. Journal of medical virology. 2021 ;93(2):733-40.

Google Scholar 10.1002/jmv.26360

50. Lohia P, Nguyen P, Patel N, Kapur S. Exploring the link between vitamin D and clinical outcomes in COVID-19. American journal of physiology Endocrinology and metabolism. 2021 ;320(3):E520-e6.

Google Scholar 10.1152/ajpendo.00517.2020

51. Cereda E, Bogliolo L, Klersy C, Lobascio F, Masi S, Crotti S, et al. Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital. Clinical nutrition (Edinburgh, Scotland). 2020 ;40(4):2469-72.

Google Scholar 10.1016/j.clnu.2020.10.055

52. Pizzini A, Aichner M, Sahanic S, Böhm A, Egger A, Hoermann G, et al. Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry. Nutrients. 2020 ;12(9).

Google Scholar 10.3390/nu12092775

53. Szeto B, Zucker JE, LaSota ED, Rubin MR, Walker MD, Yin MT, Cohen A. Vitamin D Status and COVID-19. Clinical Outcomes in Hospitalized Patients. Endocr Res. 2021 Feb-May ;46(2):66-73.

Google Scholar 10.1080/07435800.2020.1867162

54. Karahan S, Katkat F. Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey. The journal of nutrition, health & aging. 2021 ;25(2):189-96.

Google Scholar 10.1007/s12603-020-1479-0

55. Vassiliou AG, Jahaj E, Pratikaki M, Orfanos SE, Dimopoulou I, Kotanidou A. Low 25-Hydroxyvitamin D Levels on Admission to the Intensive Care Unit May Predispose COVID-19 Pneumonia Patients to a Higher 28-Day Mortality Risk: A Pilot Study on a Greek ICU Cohort. Nutrients. 2020 ;12(12):3773.

Google Scholar 10.3390/nu12123773

56. Infante M, Buoso A, Pieri M, Lupisella S, Nuccetelli M, Bernardini S, et coll. Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study. Journal of the American College of Nutrition [En ligne]. 18 fév 2021 [cité le 20 mars 2021]:[environ 16 p.]. Disponible : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899172/

Google Scholar 10.1080/07315724.2021.1877580

57. De Smet D, De Smet K, Herroelen P, Gryspeerdt S, Martens GA. Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality. American journal of clinical pathology. 2021 ;155(3):381-8.

Google Scholar 10.1093/ajcp/aqaa252

58. Carpagnano GE, Di Lecce V, Quaranta VN, Zito A, Buonamico E, Capozza E, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2021 ;44(4):765-71.

Google Scholar 10.1007/s40618-020-01370-x

59. Bennouar S, Cherif AB, Kessira A, Bennouar D-E, Abdi S. Vitamin D Deficiency and Low Serum Calcium as Predictors of Poor Prognosis in Patients with Severe COVID-19. Journal of the American College of Nutrition. 2021 ;40(2):104-10.

Google Scholar 10.1080/07315724.2020.1856013

60. Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr. 2021 ;60(1):545-8.

Google Scholar 10.1007/s00394-020-02372-4

61. Arvinte C, Singh M, Marik PE. Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study. Med Drug Discov. 2020 ;8:100064.

Google Scholar 10.1016/j.medidd.2020.100064

62. Silva MC, Furlanetto TW. Does serum 25-hydroxyvitamin D decrease during acute-phase response ? A systematic review. Nutrition Research. 2015 ;35(2):91-6.

Google Scholar 10.1016/j.nutres.2014.12.008

63. NIH. Clinicaltrials.gov [En ligne]. 2020 [cité le 20 mars 2021 ]. Disponible : https://clinicaltrials.gov/ct2/results?cond=SARS-CoV-2&term=vitamin+D&cntry=&state=&city=&dist=&Search=Search&type=Intr

Google Scholar

64. Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, Alcalá Díaz JF, López Miranda J, Bouillon R, et al. «Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study». J Steroid Biochem Mol Biol. 2020 ;203:105751.

Google Scholar 10.1016/j.jsbmb.2020.105751

65. Rastogi A, Bhansali A, Khare N, Suri V, Yaddanapudi N, Sachdeva N, et al. Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). Postgraduate Medical Journal. 2020:postgradmedj-2020-139065.

Google Scholar 10.1136/postgradmedj-2020-139065

66. CDC. Interim guidance on duration of isolation and precautions for adults with COVID-19 [En ligne]. 2021 [cité le 20 mars 2021]. Disponible : https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fcommunity%2Fstrategy-discontinue-isolation.html#references

Google Scholar

67. Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CSC, et al. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 ;325(11):1053-60.

Google Scholar 10.1001/jama.2020.26848

68. Annweiler C, Hanotte B, Grandin de l’Eprevier C, Sabatier J-M, Lafaie L, Célarier T. Vitamin D and survival in COVID-19 patients : A quasi-experimental study. J Steroid Biochem Mol Biol. 2020 ;204:105771.

Google Scholar 10.1016/j.jsbmb.2020.105771

69. Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi-Newton S, Kong MF, et al. High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients. 2020 ;12(12):3799.

Google Scholar 10.3390/nu12123799

70. Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition. 2020 ;79-80:111017.

Google Scholar 10.1016/j.nut.2020.111017

71. Annweiler G, Corvaisier M, Gautier J, Dubée V, Legrand E, Sacco G, et coll. Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study. Nutrients. 2020 ;12(11):3377.

Google Scholar 10.3390/nu12113377

72. Giannini S, Passeri G, Tripepi G, Sella S, Fusaro M, Arcidiacono G, et al. Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating Study. Nutrients. 2021 ;13(1):219.

Google Scholar 10.3390/nu13010219

73. Cereda E, Bogliolo L, Lobascio F, Barichella M, Zecchinelli AL, Pezzoli G, et al. Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy. Nutrition. 2021 ;82:111055.

Google Scholar 10.1016/j.nut.2020.111055

74. Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis. QJM: An International Journal of Medicine. 2021 ;hcab009.

Google Scholar 10.1093/qjmed/hcab009

75. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 ;12(4):988.

Google Scholar 10.3390/nu12040988

76. Chakhtoura M, Napoli N, El Hajj Fuleihan G. Commentary: Myths and facts on vitamin D amidst the COVID-19 pandemic. Metabolism. 2020 ;109:154276.

Google Scholar 10.1016/j.metabol.2020.154276

77. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. Journal of Infection and Public Health. 2020 ;13(10):1373-80.

Google Scholar 10.1016/j.jiph.2020.06.021

78. Bergman P. The link between vitamin D and COVID-19: distinguishing facts from fiction. Journal of internal medicine. 2021 ;289(1):131-3.

Google Scholar 10.1111/joim.13158

79. Ferder L, Martín Giménez VM, Inserra F, Tajer C, Antonietti L, Mariani J, et coll. Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic. American journal of physiology Lung cellular and molecular physiology. 2020 ;319(6):L941-l8.

Google Scholar 10.1152/ajplung.00186.2020

80. Sahebnasagh A, Saghafi F, Avan R, Khoshi A, Khataminia M, Safdari M, et al. The prophylaxis and treatment potential of supplements for COVID-19. European Journal of Pharmacology. 2020 ;887:173530.

Google Scholar 10.1016/j.ejphar.2020.173530

81. Chandran M, Chan Maung A, Mithal A, Parameswaran R. Vitamin D in COVID - 19: Dousing the fire or averting the storm ? –A perspective from the Asia-Pacific. Osteoporosis and Sarcopenia. 2020 ;6(3):97-105.

Google Scholar 10.1016/j.afos.2020.07.003

82. Ebadi M, Montano-Loza AJ. Perspective: improving vitamin D status in the management of COVID-19. European journal of clinical nutrition. 2020 ;74(6):856-9.

Google Scholar 10.1038/s41430-020-0661-0

83. Santé Canada. La vitamine D et le calcium : Révision des Apports nutritionnels de référence [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://www.canada.ca/fr/sante-canada/services/aliments-nutrition/saine-alimentation/vitamines-mineraux/vitamine-calcium-revision-apports-nutritionnels-reference.html

Google Scholar

84. Alberta Health Services. COVID-19 Scientific Advisory Group Rapid Evidence Brief. Vitamin D in the Treatment and Prevention of COVID-19 [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://www.albertahealthservices.ca/assets/info/ppih/if-ppih-covid-19-sag-rapid-review-vitamin-d-treatment-and-prevention-covid-19.pdf

Google Scholar

85. Santé publique Ontario. Association of Vitamin D Status with COVID-19 Incidence and Outcomes, and Health Equity Considerations [En ligne]. 2021 [cité le 9 avril 2021]. Disponible : https://www.publichealthontario.ca/-/media/documents/ncov/he/2021/02/covid-19-rapid-review-vitamin-d.pdf?la=en

Google Scholar

86. Institut national d’excellence en santé et en services sociaux (INESSS). COVID-19 et Vitamine D [En ligne]. 2021 [cité le 9 avril 2021]. Disponible : https://www.inesss.qc.ca/fileadmin/doc/INESSS/COVID-19/COVID-19_INESSS_Vitamine_D.pdf

Google Scholar

87. Ostéoporose Canada. Calcium et vitamine D [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://osteoporosecanada.ca/sante-des-os-et-osteoporose/calcium-et-vitamine-d/

Google Scholar

Revue du rôle possible de la vitamine D dans le traitement de la COVID-19 et recommandations pratiques

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